Author:
Muhammad Akram , Abid Rashid, Umme Laila , Muhammad Talha Khalil , Aisha Rassul Ashad , Rida Zainab , Gaweł SołowskiPublished in
Journal of Science Technology and Research( Volume , Issue )
1.WHO: Strengthening implementation of the global strategy for dengue fever/dengue
haemorrhagic fever prevention and control, report on the informal consulation. Geneva, WHO;
1999.
2.Ferreira GL. Global dengue epidemiology trends. Rev Inst Med Trop Sao Paulo 2012;54 Suppl
18:S5-6.
3.Gubler DJ. The economic burden of dengue. Am J Trop Med Hyg2012;86:743-
4. Rush, B 1789. An account of the bilious remitting fever as it appeared in Philadelphia, in the
summer and autumn of 1780. Rush, B. Medical Inquires and Observations. Philadelphia:
Pritchard and Hall, 104-117.
5.WHO: Dengue/dengue haemorrhagic fever. Wkly Epidemiol Rec. 2000, 75: 193-196.
6.Hynes NA. Dengue: A reemerging concern for travelers. Cleve Clin J Med 2012;79:474-82.
7.Hottz E, Tolley ND, Zimmerman GA, Weyrich AS, Bozza FA. Platelets in dengue infection. Drug
Discov Today Dis Mech 2011;8:E33-8.
8. Halstead, S Science 239 (4839): 1988. 476–481.
9.E C Holmes, S STwiddy. “The origin, emergence and evolutionary genetics of dengue virus.”
Infection, Genetics and Evolution 3 (1): 19–28. doi:10.1016/s1567-1348(03)00004-2.
PMID12797969.2003.
10.Template for Placing Diseases or Conditions Under National Surveillence, Council of State
and Territorial Epidemiologists. Revised 2008, page 7.
11.Yunita F, Hanani E. The effect of Carica papaya L leaves extract capsule on platelet count and
hematocrit level in dengue fever patient. Int J Med Aromat Plants 2012;2:573-8.
12.Dengue Fever/Dengue Haemorrhagic Fever and its control – status in WHO’s Western Pacific
region by 1999.
13.C K Kokate, A P Purohit, S P Gokhale. Pharmacognosy 26th Edition published by
NiraliPrakashan. 348, 581, 594.
14. Mohammad Ali. Textbook of pharmacognosy 2nd edition published by CBS publishers and
distributors. 380, 381, 325.
15.R Angary, D Vinod. Pharmacognosy and phytochemistry Parttwo 1st edition. Published by
career publications.133, 192, 250.
16. Rajagopal, R., Karthick, R., Meenalochini, P., & Kalaichelvi, T. (2023). Deep Convolutional
Spiking Neural Network optimized with Arithmetic optimization algorithm for lung disease
detection using chest X-ray images. Biomedical Signal Processing and Control, 79, 104197.
17. Srinivas, T. Aditya Sai, B. Ravindra Babu, Miskir Solomon Tsige, R. Rajagopal, S. Devi, and
Subrata Chowdhury. “Effective implementation of the Prototype of a digital stethoscope using a
Smartphone.” In 2022 International Conference on Innovative Computing, Intelligent
Communication and Smart Electrical Systems (ICSES), pp. 1-8. IEEE, 2022.
18. Rajagopal, R., M. Karthik, M. Soni, Narayan Krishan Vyas, S. Hemavathi, and M. R. Arun.
“Monitoring the high-speed engine application using ferro magnetic system.” Materials Today:
Proceedings (2022).
19. Babu, P. Ramesh, Vemuri Kusuma Priya, N. Drawin, R. Thiagarajan, and R. Krishnamoorthy.
“Enhanced Hybrid Resource Scheduler for an Institution Employing NB-RR Scheduling.” In 2022
8th International Conference on Smart Structures and Systems (ICSSS), pp. 1-6. IEEE, 2022.
20. Jose, S. Edwin, R. Lal Raja Singh, and R. Rajagopal. “Automatic and real time classification of
power quality disturbance using statistical moments.” AIP Conference Proceedings. Vol. 2327.
No. 1. AIP Publishing LLC, 2021.
ABSTRACT:
Dengue fever results from the bite of the Aedes aegypti mosquito, which belongs to the Flaviviridae virus family and includes four serotypes. Infected individuals typically experience a high fever of 40 °C (104 ℉). The symptoms range from mild or asymptomatic to severe cases involving hemorrhage and shock. Many patients develop hemorrhagic dengue fever and suffer from decreased platelet counts, leading to leucopenia. Although no specific medical treatment exists, researchers and practitioners have identified several herbal treatments for dengue fever. These natural remedies aim to support the immune system and restore platelet levels. Among these, papaya leaf extract stands out as the most effective herbal remedy in increasing platelet count and alleviating symptoms. Many cultures have applied this treatment traditionally, and it continues to gain scientific attention. Thus, in the absence of a specific antiviral therapy, herbal remedies offer supportive care for managing dengue fever effectively and naturally.
INTRODUCTION:
Dengue fever spreads primarily through the bite of the female Aedes aegypti mosquito, which transmits the virus from the Flaviviridae family. This infectious disease often strikes during the daytime and has grown to alarming levels in recent years. Studies show that dengue now causes more harm than malaria in terms of morbidity and mortality. People commonly refer to it as “Breakbone Fever” due to the intense joint pain it can cause. In some cases, the virus passes from mother to child during pregnancy or through infected blood transfusions. Patients experience symptoms such as high fever (40 °C or 104 ℉), severe flu, fatigue, and joint pain. This widespread mosquito-borne disease demands better management methods. As synthetic drugs fail to offer a complete cure, herbal treatment of dengue fever—such as using papaya leaf extract—has shown potential in boosting platelet counts and improving recovery outcomes for affected individuals.
